EXTINGUISE THE FIRE OF INFLAMMATION
Using Nitric Oxide
NATHAN S. BRYAN PH.D
2024
Quantum University Alumnus
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All of the major chronic diseases, despite their underlying etiology, have the same hallmarks of ischemia, oxidative stress, immune dysfunction which all lead to uncontrolled chronic inflammation. Inflammation has been regarded as the “silent killer” for many decades now. Inflammation refers to your body’s process of fighting against things that harm it, like infections, injuries, and toxins, in an attempt to heal itself. Signs of inflammation refer to the heat (calor), pain (dolor), redness (rubor), and swelling (tumor) that characterize the clinical symptoms of inflammation as they were defined in the first century AD by the Roman scholar Celsus. The first stage of inflammation is when immune cells and platelets start to stick to the lining of the blood vessels. This causes a disruption in blood flow, activation of immune cells and production of oxygen radicals that causes oxidative stress. When left unresolved, this causes damage to organs and to the blood vessels. In order to effectively treat and mitigate inflammation without affecting our body to respond normally to injury and infection, we must first understand the mechanism of inflammation and then apply principles of applied physiology to restore normal biological functions. It appears that a single molecule, nitric oxide may be the master regulator of inflammation.
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Nitric oxide is an endogenous signaling molecule that is produced throughout the body in many cell types to regulate many important physiological processes. Nitric oxide has been shown to inhibit the earliest stages of microvascular inflammation [3]. Nitric oxide also controls the oxidative stress and immune dysfunction that occurs during inflammation [3]. If you can turn on nitric oxide production during the earliest stages of inflammation you can control the inflammatory response as intended. Without nitric oxide production, the inflammation does not turn off and chronic inflammation occurs and chronic inflammation contributes to every major chronic disease.
N1O1 Supplements
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Since nitric oxide appears to be critical for controlling inflammation, the key question becomes, how do we restore the production of NO. To answer this fundamental question, we must first understand how the body makes NO and then what goes wrong in people that become deficient. The functional loss of NO production through the enzyme nitric oxide synthase (NOS) in the endothelium is termed endothelial dysfunction. This enzymatic loss of NO precedes the structural changes (arterial stiffness, plague deposition, etc) in the blood vessel by many years sometimes decades and correlates with cardiovascular risks [4-7]. This type of vascular dysfunction occurs throughout the entire cardiovascular system and affects every organ in the body. Without sufficient NO production, this leads to the loss of regulation of blood flow and circulation in every organ. As a result, blood pressure, inflammation, oxidative stress and immune dysfunction increase. As we age, we lose our ability to synthesize NO from L-arginine (endothelial dysfunction) [8].
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How do you find a product that can overcome all the limitations of patients who are nitric oxide deficient? This can only be achieved by finding a product that produces nitric oxide gas. If your body can’t make nitric oxide, then it must be repleted. Giving pre-cursors or substrates will not work. We can do this in the form of a lozenge that releases nitric oxide gas as it is dissolving in the mouth that is completely independent and does not rely on the oral microbiome or stomach acid. We can do this through powder forms that when dissolved in water and taken as a shot generate nitric oxide gas. There is really no other way to deliver nitric oxide outside a clinical setting.
Nitric Oxide benefits
Dr. Nathan S. Bryan
As you can see from above, if you simply fix your nitric oxide production, the nitric oxide does everything else. It prevents the inflammation, oxidative stress and immune dysfunction that causes chronic disease. Nothing is more important for your health than ensuring your body makes enough nitric oxide and to restore endogenous NO production. We know how to make nitric oxide. More than 185,000 scientific publications reveal just how important this molecule is. Without it, you get sick and disease. With it, you have good health, free of disease. It’s that simple.
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