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How To Biohack Your Immune System This Winter

Top Biohacks for a Strong Immune System This Winter

DAVE ASPREY

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The holidays are upon us, and so is cold and flu season. Studies show that in the winter months you’re much more likely to get sick. That’s if you’re average. But you’re not average – you're a biohacker. 


Here are 5 of my top hacks for a resilient immune system all winter long:

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1. Load up on minerals

Fancy supplements are great but many people forget the basics – including minerals, which power every chemical reaction that occurs in your body. Your immune system depends heavily on minerals. For example, zinc helps prevent bacteria and viruses from entering your cells [1] and selenium is essential for immune cell development [2]. The problem is that most people aren’t getting enough minerals because our soil is not as nutrient-rich as it used to be. On top of that, we’re eating more anti-nutrient-containing plant foods that prevent mineral absorption. So, it’s best to take a supplement. I take the one from my company, Suppgrade Labs. It contains the right minerals in the right forms and ratios.


2. Take your vitamin D  (with vitamin K2)

Vitamin D is one of the most important nutrients for a strong immune system. Vitamin D helps your body recognize and destroy pathogens [3] and makes your immune cells stronger [4]. Most longevity doctors recommend blood levels of 25-hydroxyvitamin D, or 25(OH)D—the parameter used to assess vitamin D status—of 70 to 90 nanograms per milliliter (ng/mL).

Some people can get enough vitamin D from sun exposure but that’s only if you have enough skin exposed to the sun for a long enough time and you have the right type of vitamin D receptor settings in your genes. You can also get vitamin D from some foods, but you’re unlikely to meet your requirements with food (or sun) alone.


If you’re like most people, you’ll want to take a supplement to support vitamin D levels for peak performance. Vitamin D3 is the most bioavailable form and make sure to always take it with vitamin K2. Everyone responds differently to supplementation. The best strategy is to take a combined fat-soluble vitamin supplement (like vitamin DAKE) and then add additional vitamin D3 until your blood levels reach 70-90 ng/dL.

Top Biohacks this Winter

Dave Asprey

3. Get hot and cold

Cryotherapy is a form of mild stress that makes your immune system stronger. Studies show that cold therapy increases your levels of natural killer cells, which are your immune system’s lead defense against viruses and diseases [5]. You can get benefits from just 3-6 minutes a few times a week. Cold therapy is preventative. If you’re already sick or stressed, skip the ice bath. It can make things worse.


If you’ve already caught something, you may do better with a sauna session. Whole-body heating can mimic a fever and help the body inactivate viruses and bacteria [6]. You can get the benefits from a dry sauna, a steam sauna, hot tub, or even a hot bath but the best form of heat therapy is an infrared sauna. Infrared saunas heat you from the inside out, encouraging your cells to do a deep detox.


4. Rinse your sinuses

One of the ways bacteria and viruses enter your body is through your nose. Sinus rinses can help remove pathogens from your sinuses and may reduce your chances of getting sick [7]. You can use a simple saline spray, a neti pot, or you can even do it in a sterilized bowl with clean salt water.  You can get extra anti-microbial benefits by adding some xylitol, grapefruit seed extract or iodine. Learn more about how to do a sinus rinse properly here.

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5. Do ozone therapy

Doctors have used ozone therapy safely for over a century. Ozone disrupts pathogens, rendering them inactive. Studies also show that ozone stimulates the immune system, making you more resilient to viruses and bacteria [8]. You can do ozone therapy a number of different ways. The easiest way is to purchase a home unit and learn to do it yourself. I find that ear or nasal insufflation work really well for sinus issues and head colds. Just make sure you work with a doctor or know how to do this properly because breathing ozone into your lungs is not good. You can also get a more systemic effect by doing vaginal or rectal insufflation (#reversefart). If you want to bring out the big guns, ten-pass ozone is the strongest and most effective ozone treatment for most issues. A physician pulls some blood out of your body, infuses it with ozone, and then recirculates it, ten times in a row.


You don’t have to get sick this winter. Incorporate one (or all 5) of these hacks for peak resilience and strength!

Dave Asprey

How to Biohack this Winter

1. Wessels, I., Rolles, B., & Rink, L. (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in immunology, 11, 1712. https://doi.org/10.3389/fimmu.2020.01712.

2. Kiremidjian-Schumacher L, Stotzky G. Selenium and immune responses. Environ Res. 1987 Apr;42(2):277-303. doi: 10.1016/s0013-9351(87)80194-9. PMID: 3552651.

3. Mailhot, G., & White, J. H. (2020). Vitamin D and Immunity in Infants and Children. Nutrients, 12(5), 1233. https://doi.org/10.3390/nu12051233

4. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013 Jul 5;5(7):2502-21. doi: 10.3390/nu5072502. PMID: 23857223; PMCID: PMC3738984.

5. Brenner IK, Castellani JW, Gabaree C, Young AJ, Zamecnik J, Shephard RJ, Shek PN. Immune changes in humans during cold exposure: effects of prior heating and exercise. J Appl Physiol (1985). 1999 Aug;87(2):699-710. doi: 10.1152/jappl.1999.87.2.699. PMID: 10444630.

6. Cohen M. (2020). Turning up the heat on COVID-19: heat as a therapeutic intervention. F1000Research, 9, 292. https://doi.org/10.12688/f1000research.23299.2

7. Huijghebaert, S., Parviz, S., Rabago, D., Baxter, A., Chatterjee, U., Khan, F. R., Fabbris, C., Poulas, K., & Hsu, S. (2023). Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes. Frontiers in public health, 11, 1161881. https://doi.org/10.3389/fpubh.2023.1161881

8. Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of natural science, biology, and medicine, 2(1), 66–70. https://doi.org/10.4103/0976-9668.82319

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