What You Eat Affects How Much You Eat: How to Outsmart Hunger with Science
Dr. Bobby Dubois
NOV 2025
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Do you find yourself reaching for a second helping even when you've eaten quite a few calories? Or struggling to cut back on calories, only to feel constantly unsatisfied? You’re not alone—and it turns out that how much we eat is heavily influenced by what we eat. I’ve personally seen this play out in my own life and at my dinner table with my wife, Gail, who recently started cutting out flour and sugar while upping her vegetable intake. Her take? She’s fuller, longer. And for me, starting with a bit of protein before a meal seems to dial down my hunger. So, I dug into the research. What does the science say?
If you wish to listen to my podcast on this topic, find it here. Or watch my YouTube here.
Let’s explore five key factors that influence satiety—and how you can use them to your advantage.
1. Calorie Density: Not All Bites Are Created Equal
Imagine the difference between a handful of celery and a slice of cheesecake. The first fills your stomach with minimal calories; the second packs in hundreds. That’s calorie density—how many calories are packed into each bite.
In a randomized controlled trial using a crossover design, researchers compared meals of differing calorie densities in 69 individuals with healthy BMIs. Those who ate higher-calorie, higher-fat meals (using full-fat ingredients like regular mayonnaise and darker chicken meat) ended up consuming an additional 484 calories compared to those given a lower-calorie, lower-fat version of the same meal (source).
The takeaway? Choosing foods that are bulky but lower in calories—like vegetables, whole grains, and legumes—can help you feel satisfied without overdoing it.
2. Texture: The Power of the Chew
Texture matters more than you think. A study in 50 healthy young adults compared soft versus hard meals—think mashed potatoes versus multigrain rice with raw veggies. The result? Participants ate 20% more calories and food by weight with the softer-textured meal (study).
Another favorite of mine is the apple study. Participants were given either a whole apple, applesauce, or apple juice before a meal. Those who ate the apple ended up consuming 187 fewer calories than those who had juice (study)—despite all options having the same calorie content. The fiber and chewing likely played a major role in satiety.
3. Protein: Nature’s Hunger Suppressant
Protein has a unique ability to keep us full. In one small study of 11 men, participants who had a high-protein snack postponed their next meal by 60 minutes, compared to just 34 minutes for high-carb snacks and 25 minutes for high-fat ones (source).
From personal experience, having a small protein-rich bite 15–20 minutes before a meal helps me significantly curb my appetite—and this research supports that approach.
4. Water: Simple and Effective
A glass of water before a meal may go further than just hydrating you. In one randomized study, drinking water before eating made participants feel fuller and eat less (study).
Looking at longer-term effects, a systematic review found that consuming 500 ml of water before meals, over 3 to 12 months, led to significant weight loss across multiple randomized trials (JAMA Network).
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5. Mind Over Meal: What You Think You’re Eating Matters
One of my favorite studies in this space is the “sham milkshake” experiment. Participants drank identical 380-calorie milkshakes but were told they were either "indulgent" (620 calories) or "light" (140 calories). Those who believed they were consuming the higher-calorie shake reported greater satiety—and their hunger hormone levels (ghrelin) matched their beliefs, not the actual nutritional content (Stanford study).
Your perception plays a role in how full you feel—something to keep in mind the next time you’re reaching for seconds.
Practical Takeaways and a Simple Self-Experiment
The evidence isn't perfect—most studies are small, and many use healthy-weight individuals as subjects. But the trends are compelling enough to justify trying these strategies in your own life. As I often say, it’s time to run an N-of-1 trial (see Episode 27 for a full walkthrough). Here’s what to try:
Start your meal with a small protein snack.
Drink a glass of water before eating.
Choose foods that require more chewing and are less calorie-dense.
When possible, eat whole foods (like apples) over processed versions (like juice).
Be mindful of how you frame your food—your expectations can influence your satisfaction.
Final Thoughts
Hunger isn’t just about willpower. It’s a complex interplay of biology, perception, and behavior. But with just a few strategic shifts in what you eat and how you eat it, you can make satiety your ally. The goal isn’t to feel deprived—it’s to feel satisfied, nourished, and in control.
Until next time—be kind to yourself, fuel your intentions, and stay curious.
Disclaimer:
Contributor content reflects the personal views and experiences of the author and does not necessarily represent the views of Biohack Yourself Media LLC, Lolli Brands Entertainment LLC, or any of their affiliates. Content is provided for editorial, educational, and entertainment purposes only. It is not medical or dental advice. Always consult qualified professionals before making health decisions. By reading, you agree to hold us harmless for reliance on this material. See full disclaimers at www.biohackyourself.com/termsanddisclaimers
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