DR. BOZ'S METABOLIC MISSION

How One Physician is Transforming Lives with Ketogenic Nutrition

COURTNEY MCGEE

2025

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When Dr. Annette Bosworth — known widely as Dr. Boz — left the corporate corridors of traditional medicine to start her own clinic, she wasn’t just walking away from the system. She was walking toward a radical reinvention of how we heal.

An internal medicine physician, author, and media personality, Dr. Boz now spearheads a movement grounded in the science of ketogenic nutrition and metabolic health. Her mission is simple yet profound: reverse chronic disease by changing how we fuel our bodies.

“I left the herd,” Dr. Boz said in an interview with TereZa Hakobyan-Lolli and Anthony Lolli, Editors-in-Chief of longevity and wellness platform Biohack Yourself, for the influential upcoming women’s health documentary, “sHEALed.” “The system is meant for acquiring problems and coding them for prescriptions. That’s not medicine. That’s management. I wanted to actually help people get better.”

The sHEALed Documentary is the sister documentary to Biohack Yourself, which became a massive success after exploding on the scene in December 2024 and ignited a firestorm of interest in information focused on health and longevity. Biohack Yourself features 114 prominent and respected high-profile politicians, doctors, bestselling authors, Ph.D.s, M.D.s, scientists, chemists, inventors, biotech investors, and world-renowned academics. Stemming from the success of Biohack Yourself, TereZa Hakobyan-Lolli and Anthony Lolli have grown Biohack Yourself Media to become the number one resource for health news, publishing over 500 articles ranging from breaking news to peer reviewed content.

A Personal Turning Point

The catalyst for her transformation was personal. In 2015, her mother — then 71, frail, and riddled with cancer — refused a second round of chemotherapy. “She looked like a 90-year-old zombie,” said Dr. Boz. “Her brain was broken, her immune system was failing, and the cancer was back.”

Faced with the question no doctor wants to answer — “What would you do if it were you?” — Dr. Boz made a choice that would define her career. “I’d been studying the ketogenic diet and the role of glucose in cancer. So I took her home, taught her what a ketone is, and we started the messiest ketogenic diet you can imagine.”

Six weeks later, her mother’s tumor markers had dropped by 70%.

It was a medical miracle grounded in metabolic science.

“I had evidence for the first time that changing the fuel in our cells could reverse disease,” she said. “If I could do that with cancer, what else could I reverse?”

What Is Therapeutic Ketosis?

Unlike popular versions of the “keto diet” that often focus on macros and marketing, Dr. Boz practices what she calls therapeutic ketosis — a medically supervised, measurable, and targeted intervention aimed at cellular repair.

“You’re not keto unless you’re measuring ketones,” she insists. “Therapeutic ketosis means fueling your cells with ketones, not glucose. That changes how your brain, immune system, and even your skin function.”

Among the most remarkable outcomes in her clinic? Patients who lost 100+ pounds without needing skin reduction surgery. “When fat is burned in a ketogenic state, the body recycles the extra skin proteins,” she explained. “That doesn’t happen with standard weight loss.”

She attributes this to a process called apoptosis, or programmed cell death. “In ketosis, your body says: ‘That fat cell isn’t being used — let’s recycle it.’ It’s elegant, efficient biology.”

Key Health Benefits

Dr. Boz has seen therapeutic ketosis improve or reverse conditions such as:

Type 2 diabetes
Autoimmune disorders
Depression and anxiety
Insomnia
Chronic fatigue
Dementia symptoms
Obesity and metabolic syndrome
Hormonal imbalances

“Six weeks into therapeutic ketosis and people are sleeping through the night, off arthritis medications, and saying their brain feels alive again,” she shared. “We change the fuel, and the system starts repairing itself.”

From Doctor to Teacher

After her mother’s transformation, Dr. Boz wrote a book about the experience — Any Way You Can — which has since sold over a million copies. “It was messy, emotional, and completely honest,” she said. “We were doing whatever we could to save her life.”

But writing was only the beginning. Her YouTube channel grew rapidly, and she found herself inundated with patients who couldn’t afford or access in-person care.

So she created a solution: a three-week online course called “Keto Continuum.” In her first run, 200 students paid $1,000 each to attend daily Zoom lessons and support groups. The results were transformative.

“They didn’t need a doctor. They needed a teacher and a tribe,” she said. “I could’ve taken four years in clinic to get those same results. Instead, we did it in 21 days.”

The Power of Community

Dr. Boz now hosts a free weekly support group online, providing accountability, education, and encouragement. “People think they’re alone in this struggle. But when they hear someone else say the same thing — that’s when real change happens.”

Her community-driven model underscores a central truth often forgotten in medicine: healing is social. “Behavior doesn’t change in a vacuum,” she said. “It changes in relationship.”

Action Items for Better Health

Based on Dr. Boz’s insights, here are practical steps anyone can take to start improving their metabolic health today:

Track Your Ketones: You’re not in ketosis unless you measure it. Use a blood ketone meter or ketone breath analyzer to confirm you’re producing ketones.
Drop Total Carbohydrates to 20g/Day: This threshold initiates ketosis for 98% of people. “It’s a shock to the system,” says Dr. Boz, “but it works.”
Use Exogenous Ketones and MCTs for Support: Supplements like C8/C10 medium-chain triglycerides (MCTs) can help kickstart ketosis or support during transition periods.
Join a Support Group: Don’t go it alone. Look for communities like Dr. Boz’s weekly group or structured programs to stay accountable.
Consider GLP-1 for Advanced Support: Dr. Boz sees promise in using microdoses of GLP-1 agonists for patients with stubborn insulin resistance. “They’re game-changers for mood, hunger, and brain function.”
Clean the Cell, Not Just the Scale: “Weight loss is a side effect,” she says. “We’re cleaning out trash at the cellular level — that’s what really heals.”

Respect Hormonal Intelligence: Insulin, the dictator of metabolism, suppresses other hormones like estrogen and testosterone. Lowering insulin is essential to unlocking true hormonal health.

The Science of Estrogen and the Aging Female Brain

One of Dr. Boz’s most powerful insights involves women’s health — especially during menopause.

In 2024, researchers confirmed for the first time that human female brains have estrogen receptors that increase in density after menopause. “Our brains are hungry for estrogen as we age — not less, but more,” she said.

Yet for decades, women were told they didn’t need estrogen replacement. “We thought the brain fog, fatigue, and memory loss was just aging,” she said. “Now we know it was preventable.”

Her message to women: Don’t fear estrogen. But more importantly, control insulin. “Insulin outranks estrogen. If it’s too high, your hormones are trapped in fat cells and can’t function.”

She also emphasized an unlikely but evidence-backed strategy for cognitive health: routine orgasms. “It’s now proven that sexual activity improves brain function in postmenopausal women,” she said. “And no, we didn’t know that until 2024 because — believe it or not — until recently, all sexual brain imaging was done on men.”

A Bigger Mission

Dr. Boz hopes her work not only educates individuals but informs policy.

“Healthcare policy is disconnected from patient reality,” she said. “We need systems that support prevention, education, and real metabolic health — not just prescriptions.”

Her final message is one of hope.

“I’ve been burned out. I’ve told my kids not to go into medicine. But now, with tools like GLP-1 and a better understanding of insulin, I believe we can reverse chronic disease — at scale. We just have to teach people how to fuel themselves properly.”

In a world struggling with rising rates of obesity, diabetes, dementia, and depression, Dr. Boz offers a bold, science-backed path forward — not just for surviving, but for thriving.

And it all begins with changing the fuel.

Check here for information about the upcoming spring 2025 edition Biohack Yourself Magazine, where the team at Biohack Yourself Media dives deeper into their insights on biohacking, longevity and cutting-edge wellness strategies. Biohack Yourself Magazine is the first peer-reviewed longevity publication with international distribution across the U.S. and Canada, bringing science-backed health optimization, functional medicine and performance-driven breakthroughs to a broader audience. Pick up a copy at major retailers, including Barber & Noble, Books-A-Million, Publix, Kroger, Indigo/Chapters, and select fitness gyms and pharmacies.