Smith's journey began with his pivotal book, "Seeds of Deception," which exposed the potential health risks associated with GMOs and garnered widespread attention. His subsequent works, including "Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods further cemented his reputation as a leading authority on the subject, providing comprehensive scientific evidence on the health impacts of GMOs.

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Smith's five documentaries include the award winning "Genetic Roulette: —The Gamble of Our Lives," which was viewed by millions and played extensively on PBS stations. His film “Secret Ingredients,” co-directed with Amy Hart, documents the dramatic health recoveries of individuals and families who avoided GMOs and Roundup in their foods by switching to an organic diet. His films brought visual clarity to the complex issues surrounding GMOs. These films not only elucidated the potential health hazards linked to GMO consumption but also highlighted the corporate influences shaping agricultural policies worldwide. Smith's compelling storytelling and evidence-based approach resonated globally, catalyzing public awareness that resulted in widespread rejection of GM foods by health-conscious consumers. Smith and his Institute are widely credited to have engineered the consumer rejection that limited the number of commercialized GMO foods to about a dozen.