NITRIC OXIDE BENEFITS WITH DR. NATHAN BRYAN
Master Hormone and Holy Grail of Longevity and Biohacking
DR. NATHAN BRYAN
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The field of Longevity is exploding. People are taking action to improve their health so they can live longer and better lives free of disease. Biohacking is implementing diet and lifestyle to re-program our cells to improve their efficiency and function so we can improve our performance at all levels. There are a number of scientifically and clinically proven modalities in the biohacking and longevity fields. However, there is one consideration that is foundational for optimal health and longevity. If not functional, nothing else will work. If functional, everything else works better. That consideration is NITRIC OXIDE, a hormone that must be replaced as we age.
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Most Americans know the importance of hormones. In fact, there is a huge industry of hormone replacement clinics around the world. Everybody knows the older we get, the less our body produces natural hormones including testosterone in men and estrogen in women. The time the body stops making these hormones is called andropause in men and menopause in women. There are amazing health benefits of hormone replacement when done correctly.
There are many other important hormones that we should also consider such as thyroid hormone, cortisol, and many others. Most people do not think of nitric oxide as a hormone but back in 2007, my lab was the first to demonstrate that nitric oxide acted as a hormone. Hormones are chemical substances that act like messenger molecules in the body. After being made in one part of the body, they travel to other parts of the body to affect specific activities. Prior to our study in 2007 it was thought that nitric oxide could only act in the cell in which it was produced (autocrine) or a neighboring cell (paracrine). Our seminal paper showed that nitric oxide produced in a single organ or compartment had systemic effects that could signal and protect all other organs. This was a game changer in nitric oxide biochemistry and physiology. But the question was how could it do this since nitric oxide, once produced, is gone is less than one second.
The answer is in the more stable metabolites it forms once produced in the body. Nitric oxide is converted to nitrite and also binds to glutathione once produced to form a molecule called S-nitrosoglutatione. These two molecules extend the biological half-life of nitric oxide from 1 millisecond out to tens of minutes and hours. This allows nitric oxide to affect many other organs systemically and act as a hormone. The original discovery of nitric oxide was as a signaling molecule that led to a Nobel Prize in 1998. However, it wasn’t until our 2007 publication that revealed that nitric oxide is a hormone signaling molecule capable of affecting every organ, tissue and cell in the body when produce anywhere in the body.
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Benefits of vasodilated blood vessels
The inner most cells of our blood vessels is called the endothelium. The endothelium is our largest organ and the main site of nitric oxide production, making it also an endocrine gland that secretes NO gas upon stimulation. Every organ in the body is controlled by its own blood supply. The blood supply to every organ is regulated by the function of its own endothelial cells and its ability to produce nitric oxide.
We’ve known for centuries now that every major chronic disease is characterized by a diminished blood supply and reduced circulation to that organ. We see it in Alzheimers’ Disease, heart disease, kidney disease, lung disease, gastrointestinal disease and others. Without sufficient circulation, oxygen and nutrients cannot be delivered to these organs and they begin to fail.
There is increased inflammation, oxidative stress and immune dysfunction that results from decreased blood flow and decreased nitric oxide production. Similar to decreased testosterone production in the testes of men or decreased estrogen production in the ovaries in women, if there is decreased nitric oxide production in the endothelium, we get symptoms and the onset of many diseases.
Also similarly, if we replace missing hormones and restore the body’s normal production, we can reverse many symptoms and actually stop the progression of disease. That has been my objective and strategy for the past 20 years. We must replace and restore nitric oxide production in order to combat the effects of aging and age-related diseases. The question has been, how do we do that safely and effectively?
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Based on our 2007 study in the Proceedings of the National Academy of Sciences, we proved that all we had to do was generate nitric oxide in a single biological compartment and then the hormone effects would take effect. When we replace other hormones such as insulin, testosterone, estrogen or thyroid, we don’t have to give testosterone shots in the testes for it to work. We don’t have to inject insulin into the pancreas and we do not have to inject estrogen into the ovaries for it to work. We can give it in the muscle, in the subcutaneous space or apply topically and then the hormone will do its job.
Similarly, we don’t have to only produce nitric oxide in the endothelium, we can produce it anywhere in the body and it will have its effects. That is why I chose the mouth or oral cavity as a compartment to generate nitric oxide gas. I was the first and only person in the world to produce a solid dose form of nitric oxide gas. The basis is that an orally disintegrating lozenge would slowly dissolve in the mouth and as it is dissolving active ingredients would come together to produce nitric oxide gas.
Once we do that, the nitric oxide and signaling molecules produced from NO gas go systemic and nitric oxide provides its hormone function. The health benefits are measurable and profound. We get better circulation, better oxygen delivery, better stem cell function, reduced inflammation, reduced oxidative stress and better immune function. It basically reverses all of the known causes and consequences of all major chronic diseases.
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Nitric Oxide Lozenges
There are hundreds of so-called nitric oxide products on the market. Nearly all of them provide no therapeutic benefits since they do not produce nitric oxide themselves. That is the basis of my product technology that I termed “NITRICEUTICALS”. My products produce nitric oxide gas providing benefits.
This is only achieved through an orally disintegrating tablet or through our fermented beet powder that produces nitric oxide gas when placed in water. This cannot be achieved through capsules, gummies, chews that many other companies are selling. If you want the benefits of nitric oxide, then you must find a product that produces it for you. If your body cannot make nitric oxide, then my product technology does it for you. It is that simple.
Remember the quote by Stephen Hawking “The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.” Many companies out there have an illusion of knowledge and yet others deliberately try to deceive their customers. Ignorance is curable through education and the correct information. That is my goal to educate and inform you so you can make informed decisions on what is best for your health and the health of your family. After all, there is nothing more important than our own health.
Dr. Nathan S. Bryan is a biochemist and physiologist that has more than 20 years of basic science and clinical research. His many seminal discoveries have resulted in dozens of issued U.S. and International patents. He is an international expert in nitric oxide and molecular medicine. Dr. Bryan is an innovator and successful entrepreneur who product technology is responsible for hundreds of millions of dollars in revenue worldwide. This content is not intended to replace medical advice from a physician.
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