Biohacking AI Agents: A Glimpse into the “Mind” of an AI Agent
Dr. Kemar Green
AUGUST 2025
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As we enter the fourth quarter of 2025, the advent of AI agents heralds a transformative era in medicine. The pertinent question is: How should we respond? Embracing this innovation seems inevitable, as resistance would entail foregoing one of the most groundbreaking advancements in history.
AI agents hold promise in medicine, my primary professional domain, where I address rare and complex neurologic diseases through clinical practice and experimental investigations involving digital neural signatures and AI for precise diagnosis and personalized interactive digital neurotherapy at Johns Hopkins University.
Recently, I have also founded and co-founded several stealth startups directly aligned with my research and clinical work.
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Although AI agents represent a nascent phenomenon in medicine, their potential to revolutionize clinical practice is profound when implemented appropriately. Ensuring their effective integration into clinical diagnosis and treatment requires exploring the “mind” of the agent by understanding its thought processes and decision-making mechanisms.
Explainability is essential for clinicians who will only trust AI tools if these tools conceptualize data comparably to human physiological reasoning.
For instance, eye movements offer low fidelity yet insightful data on brain activity, providing a window into how an AI model processes information. Consider developing a model for cardiac disease classification using fundamental computer vision tasks inspired by the human visual pathway. Notably, my fellowship training is within the niche subspecialty of neurology encompassing neuro-eye disorders.
By visualizing what the model “sees” to differentiate between disease and non-disease states, we can assess whether its feature detection aligns with clinicians’ visual interpretations of EKG waveforms characteristic of conditions such as heart attacks. This approach grants insight into the AI’s decision-making processes, which is indispensable for refining models: Flaws cannot be rectified without understanding the underlying rationale, including why specific features are prioritized in computer vision.

This concept draws inspiration from human models wherein individuals exhibit eye signatures unique to each person, analogous to fingerprints, a discovery advanced by Dr. Oleg Komogortsev and substantiated in the literature, and further inspired by collaborations with esteemed Drs. David Zee and John Leigh of Johns Hopkins University. Similarly, AI models may display distinctive “signatures” in their waveform interpretations, potentially unique to each model or its training iteration.
Essentially, each AI has its own “mind” and chooses where on the data to fixate its digital gaze. Further research is necessary to elucidate this phenomenon. Consequently, eye movements and explainable AI will be pivotal if AI agents are to achieve widespread adoption in medicine, given that establishing physician trust forms the foundation for implementing any genetic or medical software.
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Looking ahead, the prospects are auspicious not only for AI agents but also for leveraging simple metrics such as eye movements to infer brain activity in real-time. This advancement significantly enhances non-invasive monitoring.
For biohackers, eye movements could serve to "hack" the brain, delivering high-fidelity insights without resorting to invasive procedures such as MRI. Instead, wearable devices like smart glasses could facilitate routine daily brain monitoring, providing comprehensive insights into brain health and beyond.

My recommendation is to embrace the agentic wave in medicine, with appropriate caution, as it evolves towards superhuman intelligence. If harnessed effectively, AI agents will significantly empower medical providers, better equipping them to address the complex medical challenges we face both domestically and globally. The agents are coming!
From pioneering insights to advanced AI applications with Dr. Kemar Green, neurologist, researcher, and AI innovator.
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